Conformational changes of coat proteins during vesicle formation
نویسندگان
چکیده
منابع مشابه
Molecular structures of proteins involved in vesicle coat formation.
This review includes 16 structures of vesicle coat components and accessory proteins and a description of their roles in vesicle budding or coat disassembly.
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Proteins that are destined for the secretory system usually begin their journey at the endoplasmic reticulum (ER), where proteins are translocated across the ER membrane into the lumen, before being selectively removed from the ER and packaged as cargo into transport vesicles bound for the stacks of the Golgi complex. Protein cargo then passes through the Golgi to the trans -Golgi network (TGN)...
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COPII vesicle formation requires only three coat assembly subunits: Sar1p, Sec13/31p, and Sec23/24p. PI 4-phosphate or PI 4,5-bisphosphate is required for the binding of these proteins to liposomes. The GTP-bound form of Sar1p recruits Sec23/24p to the liposomes as well as to the ER membranes, and this Sar1p-Sec23/24p complex is required for the binding of Sec13/31p. Ultrastructural analysis sh...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2007
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2007.03.020